Precision Starts at the Sidechain
Reimagine your protein–ligand complex
DRGSCROLL (Durdağı Research Group's Side Chain Rotation for Ligand Landing) is a next-generation web platform that redefines structural refinement at the molecular interface. Upload your protein and ligand, and watch as rigid docking turns dynamic, with intelligent sidechain optimization powered by genetic algorithms.
Why DRGSCROLL?
In drug discovery, accuracy isn't optional—it's everything.
While traditional docking treats sidechains as static or relies on pre-defined rotamers, DRGSCROLL uses a genetic algorithm-driven engine to search and resolve sidechain conformations that better reflect true binding interactions.
Whether you're fine-tuning a lead compound, validating a docking hypothesis, or exploring a novel interaction, DRGSCROLL reveals the structure as it wants to bind, not just as it was prepared.
DRGSCROLL
Evolution-driven side-chain optimization for precision docking.
Because your protein deserves to breathe.